Altered neurobiology of learning and memory
Please contact Dr. Susanna Rosi (firstname.lastname@example.org)
Assistant Professor, Brain & Spinal Cord Injury Center
San Francisco General Hospital
We are seeking highly motivated medical students to work with us in different projects aimed to study the altered neurobiology of learning and memory using animal models.
In my laboratory we study in vivo how local neuroinflammation and oxidative stress (induced by brain irradiation or i.c.v LPS infusion) disrupts activity patterns associated with synaptic plasticity and memory consolidation and contributes to the cognitive dysfunction associated with the initial stages of neurodegenerative diseases and neuroinflammatory-related disorders. Our long term goal is to understand how the presence of activated microglia and oxidative stress affects learning and memory. This is of critical importance for the development of strategies to prevent cognitive impairments associated with brain injury (i.e. therapeutic irradiation) and neuroinflammatory-related neurodegenerative disease (i.e. Alzheimer’s Disease).
Area of Expertise
The Job: will involve training and handling rodents for hippocampal dependent behavior experiments. Brain harvesting, dissection, and cryo- sectioning; tissues staining for immediate early gene detection using compartmental analysis of temporal activity with Fluorescent in situ Hybridization (cat-FISH) and fluorescence immunohistochemistry procedures, microscopy imaging, analysis of the data and help write it up!
The Rewards: Authorship in publications, a better understanding basic research using animal models and cutting edge molecular biology techniques, experience with scientific writing, basic statistic.
This is an excellent opportunity for students that may be interested
in understanding the mechanisms of learning and memory.
Carol Barnes, Ph.D.
Victor Ramirez Amaya, PhD.
Nigel Greig, PhD.
Almira Vazdarjanova PhD.