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2009 PBBR POSTDOCTORAL RESEARCH FELLOWS

Thomas Huckaba
Individual neurons are connected into a functional network via a specialized cellular junction called a synapse. Communication from one neuron to another takes place as a result of the activity of specialized proteins on either side of the neuronal synapse. Although a great deal of research has led to our current understanding of synaptic processes, we lack the ability to visualize individual molecular events with sufficiently high resolution to understand dynamic molecular behavior. I have initiated a collaborative project between three laboratories at UCSF that specialize in surface chemistry, cell biology, and neurobiology to develop a high-resolution microscopy assay to directly visualize the behavior of individual molecules at the neuronal synapse. Data generated from this assay will not only help us better understand the basic biology behind the formation, activation, and breakdown of neuronal synapses, but will also allow us to examine how molecular behavior changes in the disease state.

Jose Christian Perez

Nan Tang
Engineering principles of tube morphogenesis
Tubes in the lung and kidney have highly regulated sizes optimized for their individual functions. However, the mechanisms by which epithelial tubes realize the appropriate size and shape are poorly understood. My goal is to use mathematical modeling to explore the contribution of a variety of cell behaviors to the control of organ shape. This study will help to understand the complex genetic programs that govern epithelial tube morphogenesis during embryonic development.

Robert Watson

Mimi Kao

Yi Guo

Imke Listerman

Charles Kim
Intrinsic and Extrinsic Regulators of Drosophila Peripheral Nervous System Development.
Defects in neuronal development are associated with disorders such as mental retardation. Using the Drosophila peripheral nervous system as a model for neuronal development, my work will employ microarray technology to dissect the regulatory networks of intrinsic, genetically encoded programs and extrinsic, activity-influenced programs.

Matthew Hirschey

Hsin-Yen Wu
In mammalian cells, glucose is converted to acetyl-CoA, which acts as the substrate for histone acetylation. Recent studies suggested histone hypoacetylation is linked to genomic instability. Hence I am examining if reducing glucose concentration in culture media induces genomic instability in mammalian cells. Since tumors initially grow in a low glucose microenvironment, this project may be able to explain why mutations accumulate in early tumor development before angiogenesis.

Simon Tang

Jessica Harvey

Michael Cox

Robert Panizzutti

Please send inquiries to director_ope@medsch.ucsf.edu.

 

 




 

 

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