UCSF University of California, San Francisco      About UCSF       Search UCSF       UCSF Medical Center     
  Education & Training    Research    Patient Care   

Print This Page For Normal View, Click Here For Larger Font Sizes', Click Here

Latino Mental Health Research Program
Mission Statement
Manuals and Measures
Research Projects
Staff Directory


| en Español |

Research Projects


Adrián Aguilera

Pharmacotherapy and cognitive behavioral therapy are efficacious treatments of depression among diverse groups, however adherence to medication, adherence to CBT homework, and appointment attendance are barriers to effective treatmen in the community, particularly among low income populations.  This line of research seeks to investigate whether text messaging (SMS) can be used to improve adherence to treatment for depression by sending medication and appointment reminders along with using SMS as a medium for CBT homework completion to reinforce thought tracking and behavioral activation.  This project is currently in the initial feasibility/usability stage in preparation for a randomized trial.



Internet World Health Research Center

The mission of the Internet World Health Research Center (IWHRC, pronounced “I work”) is to harness the power of the Internet to reach those most in need with behavioral health interventions that are as effective as traditional interventions and that can be administered directly to them via the World Wide Web.

Smoking Cessation Web Study: Tomando Control

The Tobacco Related Disease Research Program funded the establishment of the Spanish/English Web Site for Smoking Cessation Trials at www.stopsmoking.ucsf.edu and www.dejardefumar.ucsf.edu . This project of the University of California, San Francisco/San Francisco General Hospital Latino Mental Health Research Program is being conducted in collaboration with the University of California, San Francisco Medical Effectiveness Research Center for Diverse Populations (MERC) and the University of California, San Diego. During Phase I of the study, we created the basic site and tested its ability to 1) recruit participants, 2) obtain informed consent, 3) obtain initial assessment data, 4) provide one intervention, and 5) obtain follow-up data, all with minimal human intervention. We recruited over 4500 smokers, of whom over 1000 were Spanish-speaking.
During Phase II we carried out three sets of studies comparing two smoking cessation conditions to each other. Publications from the first two phases include:

Lenert L, Muñoz RF, Stoddard J, Delucchi K, Bansond A, Skoczen S, Perez-Stable EJ (2003). Design and pilot evaluation of an internet smoking cessation program. J Am Med Inform Assoc .; 10(1):16-20.

Lenert L, Muñoz RF, Perez JE, Bansod A (2004).   Automated e-mail messaging as a tool for improving quit rates in an internet smoking cessation intervention. J Am Med Inform Assoc.; 11(4):235-40. Epub 2004 Apr 2.

Stoddard J, Delucchi K, Muñoz R, Collins N, Pérez-Stable EJ, Augustson E, Lenert L (2005).  Smoking cessation research via the internet: a feasibility study. J Health Commun.; 10(1):27-41.

Muñoz RF, Lenert LL , Delucchi K, Stoddard J, Pérez JE, Penilla C, Pérez-Stable EJ (2006 ).Toward evidence-based Internet interventions: A Spanish/English Web site for international smoking cessation trials. Nicotine & Tobacco Research, 8. 77-87.

Funding Sources
Tobacco-Related Disease Research Program Grant # 10RT-0326
“Spanish/English web site for smoking cessation trials.”
Principal Investigator: Ricardo F. Muñoz, Ph.D.

Leslie Lenert, M.D.,
Eliseo J. Pérez-Stable, M.D.,
Kevin Delucchi, Ph.D.

During Phase III, we compared four methods to stop smoking via the Web in a randomized control trial. Publications from this phase include:

Muñoz RF, Barrera AZ, Delucchi K, Penilla C, Torres LD, Pérez-Stable EJ. International Spanish/English Internet smoking cessation trial yields 20% abstinence rates at 1 year. Nicotine Tob Res. 2009 Sep;11(9):1025-34. Epub 2009 Jul 29.

Torres LD, Barrera AZ, Delucchi K, Penilla C, Pérez-Stable EJ, Muñoz RF. Quitting smoking does not increase the risk of major depressive episodes among users of Internet smoking cessation interventions. Psychol Med. 2009 Jul 23;:1-9 [Epub ahead of print]

Barrera AZ, Pérez-Stable EJ, Delucchi KL, Muñoz RF. Global reach of an Internet smoking cessation intervention among Spanish- and English- speaking smokers from 157 countries. Int J Environ Res Public Health.  2009 Mar;6(3):927-40. Epub 2009 Feb 26.
During Phase IV, we carried out an exploratory smoking cessation study on the Web to estimate smoking cessation rates in a participant's preference outcome study, in which participants choose among the several self-help elements that we have been testing in the randomized trials described above.

Phase V is currently recruiting participants in the United States.

We welcome Spanish and English speaking smokers to join our study.
English site: www.stopsmoking.ucsf.edu
Spanish site: https://www.stopsmoking.ucsf.edu/es/intro/home.aspx



Mothers and Babies: Mood and Health Project
Mamás y Bebés: El Estado de Animo y la Salud

Risk for major depression appears to be transmitted across generations. Pregnancy and the postpartum period are key periods to study because maternal emotion regulation deficits may affect both maternal and child outcomes. Children of parents with emotion regulation problems are at higher risk for developing similar problems over time.
The Mothers and Babies: Mood and Health Project was launched in 1998 by the Latino Mental Health Research Program at the University of California, San Francisco/San Francisco General Hospital. Its aims are: (1) to identify pregnant women at imminent risk for major depressive episodes, and (2) to test whether a cognitive-behavioral intervention reduces risk for maternal depression and improves maternal and child functioning in high risk low-income pregnant English and Spanish-speaking women.


Depression Management Course

Yan Leykin, Ph.D.
Ricardo Muñoz, Ph.D.

Untreated depression accounts for more than 11% of the world total disease burden.  Depression is associated with up to 60% of suicide deaths, deteriorating health, and social problems. Most affected individuals are not receiving adequate treatment.  The long-term objective of this project is to address the issue of untreated depression by developing and evaluating an effective Web-based intervention for depression, available at no cost and in multiple languages to depressed and dysphoric individuals anywhere in the world. 

The current project is the first step towards that goal.  We have developed a self-contained, interactive, modular, Web-based self-help intervention for depression. The intervention is based on cognitive-behavioral therapy, an empirically supported treatment for depression. Participants from the Internet community are invited to sign up for a customized eight-lesson intervention. This is a proof-of-concept study, with the goal of assessing the degree of interest in and the demand for Web interventions, and to obtain initial information about the effectiveness of this intervention.

We are currently recruiting participants:



Updated: March 14, 2014
    Site Map    Contact Info     ©UC Regents